Group of Prof. Franz Bracher - Faculty for Chemistry and Pharmacy


Yuan, Y.; Jaslan, D.; Rahman, T.; Bolsover, S.R.; Arige, V.; Wagner, L.W. II; Abrahamian, C.; Keller, M.; Hartmann, J.; Rosato, A.S.; Weiden, E.-M.; Bracher, F.; Yule, D.I.; Grimm, C.; Patel, S., Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes, Nat Commun 2022, 13, 4481,

Rosato, A.S.; Krogsaeter, E.; Jaślan, D.; Montefusco, S.; ,Abrahamian, C.; Soldati, C.; Spix, B.; Böck, J.; Wyatt, A.; Wünkhaus, D.; Passon, M.; Stieglitz, M.; Keller, M.; Hermey, G.; Markmann, S.; Gruber-Schoffnegger, D.; Cotman, S.; Johannes, L.; Crusius, D.; Boehm, U.; Marquardt, T.; Wahl-Schott, C.; Biel, M; Bracher, F.; Polishchuk, E.; Medina, D.L.; Paquet, D.; Grimm, C., TPC2 rescues lysosomal storage in mucolipidosis type IV; Niemann-Pick type C1 and Batten disease, EMBO Mol. Med. 2022, e15377,

Keller, M.;  Sauvageot-Witzku, K.;  Geisslinger, F.;  Urban, N.;  Schaefer, M.;  Bartel, K.; Bracher, F., The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet–Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids, Beilstein J Org Chem 2021, 17, 2716-2725, 10.3762/bjoc.17.183.

Leser, C.;  Keller, M.;  Gerndt, S.;  Urban, N.;  Chen, C. C.;  Schaefer, M.;  Grimm, C.; Bracher, F., Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3, Eur J Med Chem 2021, 210, 112966, 10.1016/j.ejmech.2020.112966.

Gerndt, S.;  Chen, C. C.;  Chao, Y. K.;  Yuan, Y.;  Burgstaller, S.;  Scotto Rosato, A.;  Krogsaeter, E.;  Urban, N.;  Jacob, K.;  Nguyen, O. N. P.;  Miller, M. T.;  Keller, M.;  Vollmar, A. M.;  Gudermann, T.;  Zierler, S.;  Schredelseker, J.;  Schaefer, M.;  Biel, M.;  Malli, R.;  Wahl-Schott, C.;  Bracher, F.;  Patel, S.; Grimm, C., Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function, Elife 2020, 9, 10.7554/eLife.54712.

Müller, M.;  Gerndt, S.;  Arner, A.;  Chao, Y.-K.;  Schömig, L.;  Atzberger, C.;  Biel, M.;  Bracher, F.;  Vollmar, A.;  Binder, V.;  Keller, M.;  Grimm, C.; Bartel, K., Reversal of Chemoresistance in Leukemia Cells using synthetic bisbenzylisoquinoline derivatives, Blood 2018, 132, 3504-3504, 10.1182/blood-2018-99-111651.

Plesch, E.;  Chen, C. C.;  Butz, E.;  Scotto Rosato, A.;  Krogsaeter, E. K.;  Yinan, H.;  Bartel, K.;  Keller, M.;  Robaa, D.;  Teupser, D.;  Holdt, L. M.;  Vollmar, A. M.;  Sippl, W.;  Puertollano, R.;  Medina, D.;  Biel, M.;  Wahl-Schott, C.;  Bracher, F.; Grimm, C., Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells, Elife 2018, 7, 10.7554/eLife.39720.

Keller, M.;  Wolfgardt, A.;  Muller, C.;  Wilcken, R.;  Bockler, F. M.;  Oliaro-Bosso, S.;  Ferrante, T.;  Balliano, G.; Bracher, F., Arylpiperidines as a new class of oxidosqualene cyclase inhibitors, Eur J Med Chem 2016, 109, 13-22, 10.1016/j.ejmech.2015.12.025.

Chen, C. C.;  Keller, M.;  Hess, M.;  Schiffmann, R.;  Urban, N.;  Wolfgardt, A.;  Schaefer, M.;  Bracher, F.;  Biel, M.;  Wahl-Schott, C.; Grimm, C., A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV, Nat Commun 2014, 5, 4681, 10.1038/ncomms5681.

Krojer, M.;  Keller, M.; Bracher, F., 7-Aza-des-A-steroids with antimicrobial and cytotoxic effects, Sci Pharm 2013, 81, 329-38, 10.3797/scipharm.1303-03.

Lange, S.;  Keller, M.;  Muller, C.;  Oliaro-Bosso, S.;  Balliano, G.; Bracher, F., Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors, Eur J Med Chem 2013, 63, 758-64, 10.1016/j.ejmech.2013.03.002.

Filippakopoulos, P.;  Picaud, S.;  Fedorov, O.;  Keller, M.;  Wrobel, M.;  Morgenstern, O.;  Bracher, F.; Knapp, S., Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family, Bioorg Med Chem 2012, 20, 1878-86, 10.1016/j.bmc.2011.10.080.

Schiefelbein, L.;  Keller, M.;  Weissmann, F.;  Luber, M.;  Bracher, F.; Friess, W., Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation, Eur J Pharm Biopharm 2010, 76, 342-50, 10.1016/j.ejpb.2010.08.012.

Cooper, G. J.;  Newton, G. N.;  Long, D. L.;  Kogerler, P.;  Rosnes, M. H.;  Keller, M.; Cronin, L., Monitoring the formation of coordination complexes using electrospray mass spectrometry, Inorg Chem 2009, 48, 1097-104, 10.1021/ic802197u.

Mathieson, J. S.;  Cooper, G. J.;  Pickering, A. L.;  Keller, M.;  Long, D. L.;  Newton, G. N.; Cronin, L., Exploring a series of isostructural dodecanuclear mixed Ni:Co clusters: toward the control of elemental composition using pH and stoichiometry, Chem Asian J 2009, 4, 681-7, 10.1002/asia.200900007.


Rautenberg, S.; Keller, M.; Leser, C.; Chen, CC.; Bracher, F.; Grimm, C., Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels, Handbook of Experimental Pharmacology (2022), Springer, Berlin, Heidelberg,

Poster- und Konferenzbeiträge

R. A. Capel, E. Akerman, R. B. A. Mu-u-min, M. Read, E. Rog-Zielinska, A. Koschinski, D. Aston, I. Jenkin, V. Brans, S. J. Bose, M. Ruas, B. V. Potter, M. Keller, F. Bracher, A. Galione, M. Zaccolo, D. A. Terrar, R. A. B. Burton; Lysosomal calcium signalling contributes to acute physiological control of heart rate at the sino-atrial node pacemaker; Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Texas, USA.

Keller, M.; Wolfgardt, A.; Müller, C.; Oliaro-Bosso, S.; Balliano, G.; Wilcken, R.; Böckler, F.; Bracher, F.; Aryltetrahydropyridine and arylpiperidine derivatives as a new class of human oxidosqualene cyclase inhibitors; Jahrestagung der DPhG, 09.10.-11.10.2013, Freiburg, Germany.

Wrobel, M.; Keller, M.; Filippakopoulos, P.; Knapp, S.; Bracher, F.; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Frontiers in Medicinal Chemistry, 18.03.-20.03.2013, München, Germany.

Schiefelbein, L.; Keller, M.; Weissmann, F.; Luber, M.; Bracher, F.; Frieß, W.; Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation; DPhG International Graduate Student Symposium, 18.11. - 21.11.2009, Pichlarn, Austria.

Keller, M.; Müller, C.; Bracher, F.; Synthesis of new and selective inhibitors of human oxidosqualene cyclase; Jahrestagung der DPhG, 28.09. - 01.10.2009, Jena, Germany.

Worbel, M.; Keller, M.; Filippakopoulos, P.; Morgenstern, O.; Knapp, S.; Bracher, F.; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Summer School, 26.09.-28.09.2013, Regensburg, Germany.

Wolfgardt, A.; Müller, C.; Keller, M.; Bracher, F.; Synthesis of new selective oxidosqualene cyclase inhibitors; Joint Meeting of the Austrian and German Pharmaceutical Societies, 20.09. - 23.09.2011, Innsbruck, Austria.

Schiefelbein, L.; Keller, M.; Bracher, F.; Frieß, W.; Relationship between hemolytic activity and critical micelle concentration (CMC) of sugar-based surfactants for protein formulations; 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 07.04. - 10.04.2008, Barcelona, Spain.