Group of Prof. Franz Bracher - Faculty for Chemistry and Pharmacy

Publications

 

J. Junker, I. Chong, F. Kamp, H. Steiner, M. Giera, C. Müller, F. Bracher: Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol. Molecules, 24(13), 2353 (2019), doi: 10.3390/molecules24132353

A. Artarini, M. Meyer, Y. J. Shin, K. Huber, N. Hilz, F. Bracher, D. Eros, L. Orfi, G. Keri, S. Goedert, M. Neuenschwander, J. von Kries, Y. Domovich-Eisenberg, N. Dekel, I. Szabadkai, M. Lebendiker, Z. Horváth, T. Danieli, O. Livnah, O. Moncorgé, R. Frise, W. Barclay, T. F. Meyer, A. Karlas: Regulation of influenza a virus mRNA splicing by CLK1, Antiviral Research 168, 187-196 (2019), doi: 10.1016/j.antiviral.2019.06.003

C. Müller, A. L. Wagner, U. Rockinger, G. Winter, F. Bracher: Development of a convenient method for the determination of dimethyl sulfoxide in lyophilised pharmaceuticals by static headspace gas chromatography – mass spectrometry. Analytical Methods 11, 2119-2122 (2019), doi: 10.1039/c8ay02574f

K. Pallauf, D. Chin, I. Günther, M. Birringer, K. Lüersen, G. Schultheiß, S. Vieten, J. Krauß, F. Bracher, N. Danylec, S. T. Soukup, S. Kulling, G. Rimbach: Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice. Scientific Reports 9:4445 (2019), doi: 10.1038/s41598-019-41050-2

C. Glas, F. Bracher: General Method for the Preparation of Indole-2-Weinreb Amides. Synthesis 51(3), 757-768 (2019), doi: 10.1055/s-0037-1610660

K. Vögerl, N. Ong, J. Senger, D. Herp, K. Schmidtkunz, M. Marek M, M. Müller, K. Bartel, T. B. Shaik, N. J. Porter, D. Robaa, D. W. Christianson, C. Romier, W. Sippl, M. Jung, F. Bracher: Synthesis and biological investigation of phenothiazine-based benzhydroxamic acids as selective histone deacetylase 6 (HDAC6) inhibitors. J. Med. Chem. 62(3), 1138-1166 (2019), doi: 10.1021/acs.jmedchem.8b01090

F. Bracher: Dimethylformamide acetals and Bredereck’s reagent as building blocks in natural products total synthesis, Mini-Reviews in Organic Chemistry 16, 1-20 (2018), doi: 10.2174/1570193X16666181204122143

A. P. R. Gadelha, B. Bravim, J. Vidal, L. C. Reignault, B. Cosme, K. Huber, F. Bracher, W. de Souza: Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor. International Journal of Medical Microbiology, 309(2), 130-142 (2019), doi: 10.1016/j.ijmm.2019.01.002

A. Kamlah, F. Bracher: A short synthesis of the plant alkaloid 4-methyl-2,6-naphthyridine. Letters in Organic Chemistry (2018) accepted, doi: 10.2174/1570178616666181116110647

E. Plesch, C.-C. Chen, E. Butz, A. Scotto Rosato, E. K. Krogsaeter, H. Yinan, K. Bartel, M. Keller, D. Robaa, D. Teupser, L.M. Holdt, A.M. Vollmar, W. Sippl, R. Puertollano, D. Medina, M. Biel, C. Wahl-Schott, F. Bracher, C. Grimm: Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. eLIFE 7, e39720 (2018) accepted, doi: 10.7554/eLife.39720

J. Krauss, F. Bracher: Pharmacokinetic Enhancers (Boosters)—Escort for Drugs against Degrading Enzymes and Beyond. Scientia Pharmaceutica 86(4), 43ff (2018), doi: 10.3390/scipharm86040043

B. Lohrer, F. Bracher: A short and divergent route to 2-alkenyl-4-quinolones. Tetrahedron Letters 59(40), 3632-3635 (2018), doi: 10.1016/j.tetlet.2018.08.062

B. Lohrer, F. Bracher: A convenient identification of carbamate-derived drug substances. Pharmazie, 73, 555-558 (2018), doi: 10.1691/ph.2018.8092

Z. Hubler, D. Allimuthu, I. Bederman, M. S. Elitt, M. Madhavan, K. C. Allan, H. E. Shick, E. Garrison, M. T. Karl, D. C. Factor, Z. S. Nevin, J. L. Sax, M. A. Thompson, Y. Fedorov, J. Jin, W. K. Wilson, M. Giera, F. Bracher, R. H. Miller, P. J. Tesar, D. J. Adams: Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature, 560, 372-376 (2018), doi: 10.1038/s41586-018-0360-3

C. Müller, T. Neugebauer, P. Zill, C. Lass-Flörl, F. Bracher, U. Binder: Sterol composition of clinically relevant Mucorales and changes resulting from posaconazole treatment. Molecules 23, 1218 (2018), doi: 10.3390/molecules23051218

F. Bracher: Methods for Arylethylation of Amines and Heteroarenes. SynOpen 2, 96-104 (2018), doi: 10.1055/s-0037-1609449

M. Moustakim, K. Riedel, M. Schuller, A. P. Gehring, O. P. Monteiro, S. P. Martin, O. Fedorov, J. Heer, D. J. Dixon, J. M. Elkins, S. Knapp, F. Bracher, P. E. Brennan: Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorganic & Medicinal Chemistry 26, 2965-2972 (2018), doi: 10.1016/j.bmc.2018.03.020

L. E. P. M van der Vlugt, K. Eger, C. Müller, D. K. Ninaber, M. C. Zarcone, G. D. Amatngalim, F. Bracher, E. von Mutius, H. H. Smits, P. S. Hiemstra: Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses. Journal of Allergy and Clinical Immunology141(5), 1949-1952.e8 (2018), doi: 10.1016/j.jaci.2018.01.025

B. Melzer, J. G. Felber,  F. Bracher: Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline. Beilstein J. Org. Chem. 14, 130-134 (2018)

K. Vögerl, D. N. Ong, F. Bracher: Reductive N-arylethylation of aromatic amines and N-heterocycles with enol ethers. Synthesis, 50, 1323-1330 (2017)

M. Schuller, K. Riedel, I. Gibbs-Seymour, K. Uth, C. Sieg, A. P. Gehring, I. Ahel, F. Bracher, B. M. Kessler, J. M. Elkins, S. Knapp: Discovery of a selective allosteric inhibitor targeting macrodomain 2 of polyadenosine-diphosphate-ribose polymerase 14. ACS Chem. Biol, 12(11), 2866–2874 (2017)

L. Fanter, C. Müller, D. Schepmann, F. Bracher, B. Wünsch: Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel s1 receptor ligands. 
Bioorg. Med. Chem. 25, 4778-4799 (2017)

D. Mailänder-Sánchez, C. Braunsdorf, C. Grumaz, C. Müller, S. Lorenz, P. Stevens, J. Wagener, B. Hebecker, B. Hube, F. Bracher, K. Sohn, M. Schaller: Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLOS One 12(10): e0184438 (2017)

M. Misslinger, F. Gsaller, P. Hortschansky, C. Müller, F. Bracher, M. J. Bromley, H. Haas: The cytochrome b5 CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus, Metallomics 9, 1655-1665 (2017)

D. N. Ong, S. Dittrich, S. Swyter, M. Jung, F. Bracher: Synthesis of highly substituted 3-arylideneindolin-2-ones, Tetrahedron 73, 5668-5679 (2017)

C. Müller, S. Hemmers, N. Bartl, A. Plodek, A. Körner, V. Mirakaj, M. Giera, F. Bracher: New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase, Eur. J. Med. Chem. 140, 305-320 (2017)

B. C. Melzer, F. Bracher: A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines, Beilst. J. Org. Chem. 13, 1564-1571 (2017)

B. R. F. Verçoza, J. L. P. Godinho, S. T. de Macedo Silva, K. Huber, F. Bracher, W. de Souza, J. C. F. Rodrigues: KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis. Apoptosis 22, 1169-1188 (2017)

I. Knappmann, K. Lehmkuhl, J. Köhler, D. Schepmann, M. Giera, F. Bracher, B. Wünsch: Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure sigma ligands with 2-benzopyran structure. Bioorg. Med. Chem. 25, 3384-3395 (2017)

C. Müller, U. Binder, F. Bracher, M. Giera: Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography-mass spectrometry. Nature Protocols 12(5), 947-963 (2017)

H. R. Nasiri, K. Hohmann, M. G. Hatemler, A. Plodek, F. Bracher, H. Schwalbe: In vitro production of reactive oxygen species (ROS) by sampangine. Med. Chem. Res. 26, 1170-1175 (2017)

J. Krauß, M. Stadler, F. Bracher: Synthesis and structure-activity relationships of novel benzylamine-type antifungals as butenafine related antimycotics. Arch. Pharm. Chem. Life Sci. 350, e1600342 (2017)

M. Stöckelhuber, C. Müller, F. Vetter, V. Mingo, S. Lötters, N. Wagner, F. Bracher: Determination of  Pesticides Adsorbed on Arthropods and Gastropods by a Micro-QuEChERS Approach and GC–MS/MS. Chromatographia 80, 825-829 (2017)

F. Vetter, C. Müller, M. Stöckelhuber, F. Bracher: Determination of coumarin in seasonal bakery products using QuEChERS and GC MS. Pharmazie 72(6), 313-316 (2017)

F. Bracher, T. Tremmel: The chemistry of the canthin-4-ones, Mini-Rev. Org. Chem. 14(2), 92-98 (2017)

F. Bracher, T. Tremmel: From lead to drug utilizing a Mannich reaction: The Topotecan story. Arch. Pharm. Chem. Life Sci. 350, e1600236 (2017)

T. A. Popp, C. Tallant, C. Rogers, O. Fedorov, P. E. Brennan, S. Müller, S. Knapp, and F. Bracher: Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. J. Med. Chem. 59(19), 8889-8912 (2016)

T. Tremmel, A. Puzik, A. P. Gehring,  F. Bracher: Canthin-4-ones as novel antibacterial agents, Arch. Pharm. 349(9), 710-723 (2016)

F. Gsaller, P. Hortschansky, T. Furukawa, P. D. Carr, B. Rash, J. Capilla, C. Müller, F. Bracher, P. Bowyer, H. Haas, A. A. Brakhage, M. J. Bromley: Sterol biosynthesis and azole tolerance is governed by the opposing actions of  SrbA and the CCAAT binding complex. PLOS Pathogens (2016), 12(7): e1005775 (2016)

S. Funke, J. Matilainen, H. Nalenz, K. Bechtold-Peters, H._C. Mahler, F. Vetter, C. Müller, F. Bracher, W. Frieß: Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature.
Eur. J. Pharm. Biopharm. 105, 209-222 (2016)

A. Karlas, S. Berre, T. Couderc, M. Varjak, P. Braun, M. Meyer, N. Gangneux, L. Karo-Astover, F. Weege, M. Raftery, G. Schönrich, U. Klemm, A. Wurzlbauer, F. Bracher, A. Merits, T. Meyer, M. Lecuit: A host genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7:11320 (2016)

T. Popp, E. Uhl, N. Ong, S. Dittrich, F. Bracher: A new approach to monoprotected 1,4-benzodiazepines via a one-pot N-deprotection/reductive cyclization procedure.
Tetrahedron 72(13), 1668-1674 (2016)

A. Plodek, F. Bracher: New perspectives in the chemistry of marine pyridoacridine alkaloids. Mar. Drugs 14(2), 26 (2016)

H. Merk, S. Zhang, T. Lehr, C. Müller, M. Ulrich, J. A. Bibb, R. H. Adams, F. Bracher, S. Zahler, A. M. Vollmar, J. Liebl: Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget 7(5), 6088-6104 (2016)

A. Kamlah, F. Lirk, F. Bracher: A new approach to 1-substituted β-carbolines and isoquinolines utilizing tributyl[(Z)-2-ethoxyvinyl]stannane as a C-3,C-4 building block. Tetrahedron 72, 837-845 (2016)

M. Keller, A. Wolfgardt, C. Müller, R. Wilcken, F. M. Böckler, S. Oliaro-Bosso, T. Ferrante, G. Balliano, F. Bracher: Arylpiperidines as a new class of oxidosqualene cyclase inhibitors. Eur. J. Med. Chem. 109, 13-22 (2015)

S. Dittrich, F. Bracher: Triflimide-catalysed rearrangement of N-(1-trimethylsilyl)allylhydrazones results in the formation of vinylsilanes and cyclopropanes. Eur. J. Org. Chem., 8024-8033 (2015)

M. J. Schuijs, M. A. Willart, K. Vergote, D. Gras, K. Deswarte, M. J. Ege, F. B. Madeira, R. Beyaert, G. van Loo, F. Bracher, E. von Mutius, P. Chanez, B. N. Lambrecht, H. Hammad: Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science 349, 1106-1110 (2015) DOI: 10.1126/science.aac6623

P. Keller, C. Müller, I. Engelhardt, E. Hiller, K. Lemuth, H. Eickhoff, K.-H. Wiesmüller, F. Bracher, S. Rupp: An antifungal benzimidazole derivative inhibits ergosterol biosynthesis and reveals novel sterols. Antimicrob. Agents Chemother. 59, 6296-6307 (2015)

K. Rüben, A. Wurzlbauer, A. Walte, W. Sippl, F. Bracher, Walter Becker: Selectivity profiling and biological activity of novel β-carbolines as potent and selective DYRK1 kinase inhibitors, PLOS One 10(7): e0132453 (2015)

T. A. Popp, F. Bracher: N-Methylation of aromatic amines and N-heterocycles under acidic conditions with the TTT (1,3,5- trioxane - triethylsilane - trifluoroacetic acid) system, Synthesis 47, 3333-3338 (2015)

B. Melzer, F. Bracher: A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines, Org. Biomol. Chem. 13, 7664-7672 (2015)

J. Krauß, U. Kopp, F. Bracher: Short microwave-assisted modular synthesis of naturally occurring oxygenated bibenzyls, Z. Naturforsch. B 70, 637-641 (2015)

C. Müller, U. Binder , E. Maurer, C. Grimm, M. Giera, F. Bracher: Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates, Steroids, 101, 1-6 (2015)

T. Tremmel, F. Bracher: New approaches to the synthesis of canthin-4-one alkaloids and synthetic analogues, Tetrahedron, 71, 4640-4646 (2015)

C. Müller, F. Bracher: Determination by GC-IT/MS of phytosterols in herbal medicinal products for the treatment of lower urinary tract symptoms and food products marketed in Europe, Planta Med., 81, 613-620 (2015)

S. Dittrich, F. Bracher: Traceless bond construction via rearrangement of N-Boc-N-allylhydrazones giving 1,1-disubstituted olefins, Tetrahedron, 71, 2530-2539 (2015)

A. Plodek, F. Bracher: A divergent approach to the total synthesis of the marine pyridoacridine alkaloid eilatin and its synthetic isomer isoeilatin. Tetrahedron Lett., 56, 1445-1447 (2015)

J. Krauß, M. Hornacek, C. Müller, V. Staudacher, M. Stadler, F. Bracher: Synthesis and antifungal evaluation of novel N-alkyl tetra- and perhydroquinoline derivatives, Sci. Pharm., 83, 1-14 (2015)

A. Plodek, M. König, F. Bracher: Synthesis of the azaoxoaporphine alkaloid sampangine and ascididemin-type pyridoacridines via TMPMgCl*LiCl mediated ring closure. Eur. J. Org. Chem., 1302-1308 (2015)

B. Strödke,  A.  P. Gehring, F. Bracher: Synthesis of desaza analogues of annomontine and canthin-4-one alkaloids, Arch. Pharm. Pharm. Med. Chem.,348, 125-131 (2015)

M. Gans, F. Bracher: First total synthesis of the marine steroid alkaloid plakinamine B, Tetrahedron, 70, 1084-1090 (2014)

M. Giera, C. Müller, F. Bracher: Analysis and experimental inhibition of distal cholesterol biosynthesis, Chromatographia, 78, 343-358 (2015)

J. Herms, K. Honarnejad, A. Daschner, A. Gehring, A. Szybinska, A. Giese, J. Kuznicki, F. Bracher: Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease, Translational Psychiatry, 4, e489 (2014)

C.-C. Chen, M. Keller, M. Heß, R. Schiffmann, N. Urban, A. Wolfgardt, M. Schaefer, F. Bracher, M. Biel, C. Wahl-Schott, C. Grimm: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV, Nature Communications, 5:4681, (2014)

B. Melzer, A. Plodek, F. Bracher: Total synthesis of the marine pyridoacridine alkaloid demethyldeoxyamphimedine, J. Org. Chem. 79, 7239-7242 (2014)

C. Grimm, L. M. Holdt, C.-C. Chen, S. Hassan, C. Müller, S. Jörs, H. Cuny, S. Kissing, B. Schröder, E. Butz, B. Northoff, J. Castonguay, C. A. Luber, M. Moser, S. Spahn, R. Lüllmann-Rauch, C. Fendel, N. Klugbauer, O. Griesbeck, A. Haas, M. Mann, F. Bracher, D. Teupser, P. Saftig, M. Biel, C. Wahl-Schott: High Susceptibility to Fatty Liver Disease in Two-pore Channel 2 Deficient Mice, Nature Communications, 5:4699, (2014)

S. Kern, S. Agarwal, K. Huber, A. P. Gehring, B. Strödke, T. Brügl, C. C. Wirth, L. O. Abodo, T. Dandekar, C. Doerig, R. Fischer, A. B. Tobin, M. M. Alam, F. Bracher, G. Pradel: Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission, PLoS ONE 9(9):e105732 (2014)

F. Bracher, J. Krauß: Medicinal chemistry and pharmacology of antifungals, Pharmakon 2, 191-199 (2014)

D.-P. Kloos, E. Gay, H. Lingeman, F. Bracher, C. Müller, O. A. Mayboroda, A. M. Deelder, W. M. A. Niessen, M. Giera: Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis, Rapid Commun. Mass Spectrom. 28, 1507-1514 (2014)

F. Vetter, J. Pohl, B. Pohl, F. Bracher: Analysis of cefaclor in novel chocolate-based camouflage capsules, Pharmazie 69, 455-457 (2014)

C. Müller, F. Vetter, E. Richter, F. Bracher: Determination of caffeine, myosmine, and nicotine in chocolate by headspace solid-phase microextraction coupled with gas chromatography-tandem mass spectrometry, J. Food Sci. 79, T251-255 (2014)

J. Krauß, E. Plesch, S. Clausen, F. Bracher: Short and efficient synthesis of alkyl- and aryl ortho-hydroxy anilides and their antibiotic activity, Sci. Pharm.82, 501-517 (2014)

A. P. Gehring, T. Tremmel, F. Bracher: One-pot conversion of 1-bromo-β-carboline and 1-bromocarbazole into pentacyclic compounds by Suzuki cross-coupling followed by spontaneous cyclization, Synthesis 46, 893-898 (2014)

J. Krauß, C. Müller, J. Kießling, S. Richter, V. Staudacher, F. Bracher: Synthesis and biological evaluation of novel N-alkyl tetra- and decahydroisoquinolines: Novel antifungals that target ergosterol biosynthesis, Arch. Pharm. Pharm. Med. Chem. 347, 283-290 (2014)

J. Lancelot, S. Caby, F. Dubois-Abdesselem, M. Vanderstraete, J. Trolet, G. Oliveira, F. Bracher, M. Jung, M., R. J. Pierce: Schistosoma mansoni sirtuins: characterization and potential as chemotherapeutic targets, PLOS Negl. Trop. Dis. 7, e2428 (2014)

P. Veiga-Santos, L. C. Reignault, K. Huber, F. Bracher, W. de Souza, T. M. Ulisses de Carvalho: Inhibition of NAD+-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi, Parasitology 141, 814-825 (2014)

M. Krojer, C. Müller, F. Bracher: Steroidomimetic aminomethyl spiroacetals as novel inhibitors of the enzyme Δ8,7-sterol isomerase in cholesterol biosynthesis, Arch. Pharm. Pharm. Med. Chem. 347, 108-122 (2014)

A. Plodek, S. Raeder, F. Bracher: A novel approach to ring A analogues of the marine pyridoacridine alkaloid ascididemin, Tetrahedron 69, 9857-9864 (2013)

J. Krauß, C. Gratzl, V. Sturm, C. Müller, V. Staudacher, C. Q. Schmidt, F. Bracher: Synthesis and biological evaluation of novel alkyl imidazolyl carbinols and their esters: potent antimycotics, Sci. Pharm. 81, 641-650 (2013)

A. Puzik, F. Bracher: 7,9,12b-Triazabenzo[a]aceanthrylen-8-one, the first representative of a novel pentacyclic ring system, and its biological activities, Lett. Org. Chem. 10, 568-572 (2013)

A. Walte, K. Rüben, R. Birner-Grünberger, C. Preisinger, S. Bamberg-Lemper, N. Hilz, F. Bracher, W. Becker: Mechanism of dual specificity kinase activity of DYRK1A, FEBS Journal 280, 4495-4511 (2013)

U. Weirauch, N. Beckmann, M. Thomas, A. Grünweller, K. Huber, F. Bracher, R. K. Hartmann, A. Aigner: Functional role and therapeutic potential of the Pim-1 kinase in colon carcinoma, Neoplasia 15, 783-794 (2013)

M. Krojer, M. Keller, F. Bracher:  Des-ring-A 7-azasteroids with antimicrobial and cytotoxic activity, Sci. Pharm. 81, 329-338 (2013)

S. Lange, M. Keller, C. Müller, S. Oliaro-Bosso, G. Balliano, F. Bracher: Aminopropylindenes derived from Grundmann’s ketone as a novel chemotype of oxidosqualene cyclase inhibitors, Eur. J. Med. Chem. 63, 758-764 (2013)

C. Müller, V. Staudacher, J. Krauß, M. Giera, F. Bracher: A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesis, Steroids 78, 483-493 (2013)

M. König. C. Müller, F. Bracher: Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase ,  Bioorg. Med. Chem. 21, 1925-1943 (2013)

A. Wolfgardt, F. Bracher: A method for the conversion of phenols into aryl tert-butyl ethers utilizing neighboring group contribution, Lett. Org. Chem. 10, 2-7 (2013)

A. Canfran-Duque, M. E. Casado, O. Pastor, J. Sanchez-Wandelmer, G. de la Pena, M. Lerma, P. Marsical, F. Bracher, M. A. Lasuncion, R. Busto: Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro, J. Lipid Res.54, 310-324 (2013)

A. Horling, C. Müller, R. Barthel, F. Bracher, P. Imming: A new class of selective and potent 7-dehydrocholesterol reductase inhibitors, J. Med. Chem. 55, 7614-7622 (2012)

A. Gehring, F. Bracher: A convenient conversion of substituted cyclohexenones into aryl methyl ketones, Synthesis 44, 2441-2447 (2012)

E. Plesch, F. Bracher, J. Krauss: Synthesis and antimicrobial evaluation of novel platensimycin analoguesArch. Pharm. Pharm. Med. Chem. 345, 657-662 (2012)

S. Raeder, F. Bracher: A novel approach to the pyridoacridine ring system – synthesis of the topoisomerase inhibitor 13-deazaascidideminArch. Pharm. Pharm. Med. Chem. 345, 822-826 (2012)

M. Luber, A. Musa, H. A. Kadry, F. Bracher: Isolation of the pyrrolizidine alkaloid intermedine-N-oxide from Cerinthe glabra and ab initio calculation of its 13NMR shifts, Z. Naturforsch. 67b, 411-416 (2012)

A. Plodek, S. Raeder, F. Bracher: Regioselective homolytic substitution of benzo[c][2,7]naphthyridines, Tetrahedron 68, 4693-4700 (2012)

R. Brauner, C. Johannes, F. Plößl, F. Bracher, R. L. Lorenz:
Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor alpha activation and expression of basolateral sterol exporter ATP binding cassette A1 in Caco-2 enterocytes, J. Nutrition 142, 981-989 (2012)

I. Wetzel, J. Krauss, F. Bracher: Enantiodivergent synthesis of (S)- and (R)-(Z)-9-dodecyl-4,5,8,9-tetrahydro-3H-oxonin-2-one as analogues of topsentolides Lett. Org. Chem. 9, 169-174 (2012)

K. Huber K, L. Brault, O. Fedorov, C. Gasser, P. Filippakopoulos, A. N. Bullock, D. Fabbro, J. Trappe, J. Schwaller, S. Knapp, F. Bracher: 7,8-Dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes, J. Med. Chem. 55, 403-413 (2012)

C. D. Mayer, L. Allmendinger, F. Bracher: Synthesis of novel steroid analogues containing nitrile and disulfide moieties via palladium-catalyzed cross-coupling reactions, Tetrahedron 68, 1810-1818 (2012)

J. Krauss, D. Köbler, V. Miller, F. Bracher: Synthesis by ring closing metathesis and cytotoxic evaluation of novel thienylmacrolactones, Sci. Pharm. 80, 29-36 (2012)

P. Filippakopoulos, S. Picaud, O. Fedorov, M. Keller, M. Wrobel, O. Morgenstern, F. Bracher, S.Knapp: Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains ofthe BET family, Bioorg. Med. Chem. 20, 1878-1886 (2012)

C. D. Mayer, F. Bracher, Cytotoxic ring A-modified steroid analogues derived from Grundmann’s ketone, Eur. J. Med. Chem. 46, 3227-3236 (2011)

Ch. Müller, F. Bracher, F. Plößl: Determination of nicotine in dried mushrooms by using a modified QuEChERS approach and GC-MS-MS, Chromatographia 73, 807-811 (2011)

O. Fedorov, K. Huber, A. Eisenreich, P. Filippakopoulos, O. King, A. N. Bullock, D. Fabro, J. Trappe, U. Rauch, F. Bracher, S. Knapp: Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing, Chemistry & Biology 18, 67 (2011)

V. Hampl, I. Wetzel, F. Bracher, J. Krauß: New substituted isocoumarins and dihydroisocoumarins and their cytotoxic activities, Sci. Pharm. 79, 59-68 (2011) 

U. Wollein, F. Bracher: The gramine route to pyrido[4,3-b]indol-3-ones – identification of a new cytotoxic lead, Sci. Pharm. 79, 21-30 (2011)

K. Huber, O. Kast, F. Bracher: A versatile synthesis of 3-substituted 4-cyano-1,2,3,4-tetrahydro-1-oxo β-carbolines, Synthesis, 3849 (2010)

L. Schiefelbein, M.Keller, F. Weissmann, M. Luber, F. Bracher, W. Frieß: Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation, Eur. J. Pharm. Biopharm. 76, 342 (2010)

H. Sanchez-Wandelmer, A. Davalos, G. de la Pena, S. Cano, M. Giera, A. Canfran-Duque, F. Bracher, A. Martin-Hidalgo, C. Fernandez-Hernando, M.A. Lasuncion, R. Busto: Haloperidol disrupts lipid rafts and impairs signaling in SH-SY5Y cells,
Neuroscience 167, 143 (2010)

S. Dietrich, F. Plößl, F. Bracher, C. Laforsch: Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna – a multigenerational study, Chemosphere 79, 60 (2010)

A. Puzik, F. Bracher: New polycyclic ring systems derived from canthin-4-one, J. Heterocyclic. Chem. 47, 449 (2010)

L. Brault, Ch. Gasser, F. Bracher, K. Huber, S. Knapp, J. Schwaller: PIM serine/threonine kinases in pathogenesis and therapy of haematologic malignancies and solid cancers (Review), Haematologica 95, 1004 (2010)

K. Huber, J. Schemies, U. Uciechowska, J. M. Wagner, T. Rumpf, F. Lewrick, R. Süss, W. Sippl, M. Jung, F. Bracher: Novel 3-arylidene-indolin-2-ones as inhibitors of NAD+-dependent histone deacetylases (sirtuins), J. Med. Chem.53, 1383 (2010)

S. Dietrich, S. Dammel, F. Plößl, F. Bracher, C. Laforsch: Effects of a pharmaceutical mixture at environmentally relevant concentrations on Gammarus fossarum, Marine and Freshwater Research 61, 196 (2010)

I. Wetzel, L. Allmendinger, F. Bracher: Revised structure of the alkaloid drymaritin, J. Nat. Prod. 72, 1908 (2009)

D. Renard, J. Perruchon, M. Giera, J. Müller, F. Bracher: Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis, Bioorg. Med. Chem. 17, 8123 (2009)

K. P. Randau, S. Sproll, H. Lerche, F. Bracher: Pernambucone, a new tropone derivative from Croton argyroglossum, Pharmazie 64, 350 (2009)

M. Lotter, F. Bracher: A short total synthesis of the marine alkaloid subarine, Sci. Pharm. 77, 1 (2009)

A. Puzik, F. Bracher: A convenient approach to the canthin-4-one ring system: Total synthesis of the alkaloids tuboflavine and norisotuboflavine, J. Heterocyclic Chem. 46, 770 (2009)

I. Wetzel, F. Bracher, J. Krauß, Short approach towards new isocoumarins and dihydroisocoumarins and investigation of their cytotoxic activities, Z. Naturforsch. B, 64b, 313 (2009)

A. Ritter, H. Poschenrieder, F. Bracher, Triethyloxonium tetrafluoroborate/1,2-dimethoxyethane – a versatile substitute for trimethyoxonium tetrafluoroborate in O-methylation reactions, Z. Naturforsch. B, 64b, 427 (2009)

F. Bracher, K. P. Randau, H. Lerche, Crototropone, a new tropone derivative from Croton zehntneri, Fitoterapia 79, 236 (2008)

J. Krauß, S. Kalkbrenner, A. Schuster, A. Obainoke, F. Bracher, Synthesis of new bengazole analogues and their antimicrobial activity, Turk. J. Chem. 32, 125 (2008)

J. Krauß, V. Knorr, V. Manhardt, S. Scheffels, F. Bracher, Synthesis of platensimycin analogues and their antimicrobial potency, Arch. Pharm. Chem. Life Sci. 341, 386 (2008)

M. Giera, F. Bracher, First total synthesis of ergosta-5,8-dien-3β-ol, Sci. Pharm.76, 599 (2008)

C. D. Mayer, M. Kehrel, F. Bracher, An improved approach to N-substituted maleimides and phthalimides by microwave-promoted mitsunobu reaction, Org. Prep. Proced. Int.,  40,  574 (2008)

M. Giera, D. Renard, F. Plössl, F. Bracher, Lathosterol side chain amides - A new class of human lathosterol oxidase inhibitors, Steroids, 73, 299 (2008)

K. Huber, F. Bracher, Cytotoxic hybrids between the aromatic alkaloids bauerine C and Rutaecarpine, Z. Naturforsch. 62b, 1313 (2007)

B. Pohl, T. Luchterhandt, F. Bracher, Total syntheses of the the chlorinated β-carboline alkaloids bauerine A, B and C, Synth. Commun. 37, 1273 (2007) 

M. Giera, F. Plössl, F. Bracher, Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post squalene pathway, Steroids 72, 633 (2007) 

C. Schmidt, R. Messmer, F. Bracher, J. Krauß, New approach towards furan containing macrolactones, Turk. J. Chem. 31, 251-256 (2007)

J. Krauß, C. Wetzel, J. Thiel, C. Neudert,  F. Bracher, Synthesis and biological evaluation of new niphatesine analogues, Arch. Pharm. Chem. Life Sci. 340, 154  (2007) 

M. Lotter, J. Schilling, E. Reimann, F. Bracher, First total synthesis of the 2,7-naphthyridine alkaloids lophocladine A and B, Arch. Pharm. 339, 677 (2006)

F. Plößl, M. Giera, F. Bracher, Multiresidue analytical method using dispersive solid-phase extraction and gas chromatography/ion trap mass spectrometry to determine pharmaceuticals in whole blood, J. Chromatogr. A 1135, 19 (2006)

J. Krauß,  D. Unterreitmeier,  F. Bracher, Short and effective synthesis of a thiophene analogue of (±)-4-ipomeanol and its biological evaluation, Turk. J. Chem. 30, 451  (2006) 

J. Krauß, F. Bracher, D. Unterreitmeier,  New approach towards cytotoxic furyl macrolactones by ring closing metathesis, Arch. Pharm. Chem. Life Sci. 339, 629  (2006) 

L. Baumann, K. Lutz, F. Bracher, Identifizierung und Unterscheidung von H2-Antihistaminika und Thioharnstoffderivaten durch Farbreaktion mit Kupfer(II)-Salzen in stark saurer Lösung, Sci. Pharm. 74, 53  (2006)

F. Dombeck, F. Bracher, Autoxidation of the antimicrobial alkaloid cleistopholine in solution, Pharmazie 61, 387 (2006)

J. Krauß, F. Bracher, D. Unterreitmeier, A new approach towards (±)-4-ipomeanol and its 2-furyl regioisomer, Turk. J. Chem. 29, 635 (2005) 

J. Krauß, D. Unterreitmeier, C. Neudert, F. Bracher,  Short and efficient approach towards macrocyclic lactones based on Sonogashira reaction, Arch. Pharm. Chem. Life Sci. 338, 605 (2005) 

F. Dombeck, F. Bracher, A hybrid between the antifungal azole eberconazole and the alkaloid onychine, Pharmazie 60, 5 (2005)

F. Bracher, W. J. Eisenreich, J. Mühlbacher, M. Dreyer, G. Bringmann,  Saludimerines A and B, novel-type dimeric alkaloids with stereogenic centers and configurationally semistable biaryl axes, J. Org. Chem. 69, 8602 (2004) 

K. Fucik, K. Kettler, J. Wiesner, R. Ortmann, D. Unterreitmeier, J. Krauß, F. Bracher, H. Jomaa, M. Schlitzer, 2-(Arylpropionylamino)- and 2-(arylacryloylamino)benzophenones: Farnesyltransferase inhibition and antimalarial activity, Pharmazie 59, 10 (2004) 

J. Krauss, I. Wetzel, F. Bracher,  A new approach towards ikimine a analogues, Nat. Prod. Res. 18, 397 (2004)

F. Bracher, D. Hildebrand, H. Häberlein, 1-Substituted β-carboline-3-carboxylates with high affinities to the benzodiazepine recognition site, Nat. Prod. Res. 18, 391 (2004) 

F. Bracher: Angriffspunkt Ergosterolbiosynthese,  Wirkstoffe und Wirkprinzipien, Pharm. uns. Zeit 32, 118 (2003)

W. J. Eisenreich, G. Höfner, F. Bracher, Alkaloids from croton flavens L. and their affinities to GABA-receptors, Natural Product Research 17, 437 (2003) 

O. Kast, F. Bracher, Unexpected ipso-substitutions at β-carboline nucleus, Synth. Commun. 33, 3843 (2003)

J. Burbiel, F. Bracher,  Azasteroids as antifungals, Steroids 68, 587 (2003)

F. Bracher, B. Schulte, Total synthesis of both enantiomers of the macrocyclic lactone citreofuran, Natural Poduct Research 17, 293 (2003)

F. Bracher, J. C. Daab;  Total syntheses of the alklaloids ipalbidinium and clathryimine B; Monatsh. Chem. 134, 573 (2003)

F. Bracher, D. Batsuren, S. Sproll, D. S. Rycroft, J. Tunsag, S. Enkahzaya, N. Batbayar, Norditerpeniod alkaloids from delphinium species, Phytochemistry 62, 543 (2003) 

A.W. Baltrusch, F. Bracher, Enantioselective synthesis of 6-nor-fluvirucinin B1, Synlett 2002, 1724

F. Bracher, J. Daab,  Total synthesis of the indolizidinium alkaloid ficuseptine, Eur. J. Org. Chem. 2002, 2288

F. Bracher, J. Krauss,  The total synthesis of both enantiomers of the macrocyclic lactone zearalane, Eur. J. Org. Chem. 2001, 4701

F. Bracher, J. Krauss, Total synthesis of (±)-zearalanone, Monatsh. Chem. 132, 805 (2001)

W. Eisenreich, F. Bracher, Crotoflavol, a new phenanthrene from Croton flavens, Natural Product Letters 15, 147 (2001)

F. Bracher, J. Krauss and S. Laufer, Effects of natural products containing acylresorcinol partial structures on cyclooxygenases and 5-lipoxygenase
Pharmazie 56, 5 (2001)

F. Bracher, J. Krauss, A. Bornatsch, Total synthesis of lunularic acid and lunularine, a new approach to natural dihydrostilbenes, Natural Product Letters14, 305 (2000) 

F. Bracher, Das Reagenz / Reagent: Trimethylaluminium, J. prakt. Chem./Chem. Ztg. 341, 88 (1999)

F. Bracher, J. Krauß, Total synthesis of secocurvularin, curvulin, and the corresponding carboxylic acids. A convenient application of the enzymatic hydrolysis of acid and base sensitive esters, Natural Product Letters 12, 31 (1998)

F. Bracher, B. Schulte, An enantiodivergent synthesis of both enantiomers of the macrocyclic lactone curvularin, Liebigs Ann./ Recueil 1997, 1979

F. Bracher, C. Berns,  Triphosgene in heterocyclic chemistry: A novel synthesis of the antiinflammatory prodrug droxicam, J. prakt. Chem./ Chem. Ztg. 339, 477 (1997)

N. Bontemps, E. Delfourne, J. Bastide, C. Francisco, F. Bracher: Total synthesis of the marine pentacyclic alkaloid meridine. Tetrahedron 53, 1743-1750 (1997);doi: 10.1016/S0040-4020(96)01096-4

F. Bracher, B. Schulte,  An enantiodivergent synthesis of both enantiomers of the macrocyclic lactone lasiodiplodin, J. Chem. Soc., Perkin Trans. 1, 2619 (1996), doi: 10.1039/P19960002619

F. Bracher, K. Klein, T. Litz,  Ein neuer Zugang zu isomerenreinem (±)-Methadon, Sci. Pharm. 64, 271 (1996)

F. Bracher, T. Litz, An efficient chemoenzymatic route to the antidepressants (R)-fluoxetine and (R)-tomoxetine, Bioorg. Med. Chem. 4, 877 (1996) 

F. Bracher, T. Papke,  3-Alkylpyridines. Part 3. Total synthesis of both enantiomers of the antineoplastic marine alkaloid niphatesine D, Monatsh. Chem.127, 91 (1996) 

F. Bracher, Polycyclic aromatic alkaloids, XII. In vitro and in vivo-investigations of the cytotoxic marine alkaloid 2-bromoleptoclinidinone, Pharmazie 52, 57 (1997)

F. Bracher, T. Papke, Polycyclic aromatic alkaloids. Part 11. A convenient formal total synthesis of the cytotoxic marine alkaloid amphimedine, Liebigs Ann. 1996, 115 

F. Bracher, T. Papke, Thiophene congeners of morpholine and allylamine type antifungals - syntheses and biological activities, Pharmazie 50, 525 (1995) 

F. Bracher, B. Schulte, A chemoenzymatic synthesis of the macrocyclic lactone (S)-curvularin, Natural Product Letters 7, 65 (1995)

F. Bracher, T. Papke, Total syntheses and antimicrobial activities of pyridine F, alkaloids from Rubiaceae, Monatsh. Chem. 126, 805 (1995), doi: 10.1007/BF00807174

Bracher, B. Schulte, An enantiodivergent synthesis of both enantiomers of the macrocyclic lactone lasiodiplodin, J. Chem. Soc., Perkin Trans. 1, 2619 (1996)


F. Bracher, T. Papke, Synthesis of 3-alkylpyridines, Part 2. Synthesis of both enantiomers of niphatesine C, J. Chem. Soc., Perkin Trans. 1, 2323 (1995) 

F. Bracher, K. Mink, First total synthesis of the 2,7-naphthyridine alkaloid neozeylanicine and unexpected formation of isoquinolines from ethoxyvinyl pyridines, Liebigs Ann. 1995, 645

F. Bracher, J. Daab, Beta-Carboline alkaloids, Part 8, Regioselective homolytic acetylation of beta-carbolines, Synth. Commun. 25, 1557 (1995)

F. Bracher, T. Litz, A chemoenzymatic synthesis of (R)-2-(1-hydroxyethyl)-1,3-dithiane, Org. Prep. Proced. Int. 27, 555 (1995)

F. Bracher, T. Litz,  2-Aryl-2 -[1-(2-hydroxypropyl)]-1,3-dithianes as versatile building blocks for the preparation of enantiomerically pure drugs, Arch. Pharm (Weinheim) 328, 235 (1995)

F. Bracher, T. Papke,  A biocatalytic approach to nonracemic 2-methyl-3-(2-thiophene)-1-propanols as chiral building blocks for the synthesis of pyridine alkaloids, Tetrahedron: Asymmetry 5, 1653 (1994)

F. Bracher, D. Hildebrand,  1,9-Dimetalated beta-carbolines. Versatile building blocks for the total synthesis of alkaloids, Tetrahedron 50, 12329 (1994) 

F. Bracher, T. Litz,  Building blocks for the preparation of enantiomerically pure drugs containing a phenylalkylamine moiety, Arch. Pharm. (Weinheim) 327, 591 (1994) 

F. Bracher, T. Papke, Synthesis of 3-alkylpyridines, Part I: Total synthesis of (±)-ikimine A, Natural Product Letters 4, 223 (1994)

F. Bracher, Seescheiden (Ascidien) - eine neue Quelle pharmakologisch aktiver Substanzen, Pharmazie in unserer Zeit 23, 147 (1994)

F. Bracher, Polycyclische aromatische Alkaloide, 10. Mitt.: Annonaceen-Alkaloide mit antimykotischer Aktivität, Arch. Pharm. (Weinheim) 327, 371 (1994) 

F. Bracher, D. Hildebrand,  Beta-Carbolin-Alkaloide, IV: Synthese von 1-Alkyl-beta-carbolinen und Strukturrevision von Lycii-Alkaloid I; Liebigs Ann. Chem. 1993, 1335 

F. Bracher, D. Hildebrand,  Beta-Carbolin-Alkaloide, II: Tributyl(1-ethoxyvinyl)stannan als C2-Baustein für die Synthese von beta-Carbolin-Alkaloiden, Liebigs Ann. Chem. 1993, 837 

F. Bracher, Polycyclische aromatische Alkaloide, 9. Mitt.: Synthese und antimykotische Wirksamkeit von Diazafluoranthen-Alkaloiden
Pharmazie 48, 521 (1993)

F. Bracher, D. Hildebrand, Beta-Carbolin-Alkaloide, I: Synthese von 1-Aryl- und 1-Alkenyl-beta-carbolinen durch Palladium-katalysierte Kupplungsreaktionen, Liebigs Ann. Chem. 1992, 1315

F. Bracher,  Polycyclic aromatic alkaloids, VIII: The structure of neocalliactine acetate -proof by total synthesis, Liebigs Ann. Chem. 1992, 1205

F. Bracher, First synthesis of the benzo[f]pyrido[2',3':3,4]pyrrolo[2,1-a][2,7]naphthyridine ring system, J. Het. Chem. 30, 157 (1993)

F. Bracher, Annonaceen-Alkaloide mit ungewöhnlichen Grundgerüsten - biologische, chemische und pharmakologische Aspekte, Pharm. Ztg. Wiss. 5, 109 (1992) 

F. Bracher,  A regioselective synthesis of azafluorenone alkaloids, Synlett 1991, 95

F. Bracher, Polycyclische aromatische Alkaloide, V.: Synthese von 2-Bromleptoclinidinon, Liebigs Ann. Chem. 1990, 205

F. Bracher, Total synthesis of the pentacyclic alkaloid ascididemin, Heterocycles29, 2093 (1989)

F. Bracher, Polycyclische aromatische Alkaloide, 2. Mitt.: Synthese von Onychin und Eupolauridin,Arch. Pharm. (Weinheim) 322, 293 (1989)

F. Bracher, Polycyclische aromatische Alkaloide, I.: Synthese von Cleistopholin und Sampangin, Liebigs Ann. Chem. 1989, 87