Dr. Marco Keller

Contact

Department of Pharmacy
Center for Drug Research
Butenandtstraße 5-13
D - 81377 Munich

Room: C 3.049
Tel. +49-89-2180-77299
Fax. +49-89-2180-77171
eMail. Enable JavaScript to view protected content.

Publications

S. Gerndt, C. C. Chen, Y. K. Chao, Y. Yuan, S. Burgstaller, A. Scotto Rosato, E. Krogsaeter, N. Urban, K. Jacob, O. N. P. Nguyen, M. T. Miller, M. Keller, A. M. Vollmar, T. Gudermann, S. Zierler, J. Schredelseker, M. Schaefer, M. Biel, R. Malli, C. Wahl-Schott, F. Bracher, S. Patel, C. Grimm; Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function; Elife; (2020); doi: https://doi.org/10.7554/eLife.54712

M. Müller, S. Gerndt, A. Arner, Y. K. Chao, L. Schömig, C. Atzbreger, M. Biel, F. Bracher, A. M. Vollmar, V. Binder, M. Keller, C. Grimm, K. Bartel; Reversal of Chemoresistance in Leukemia Cells using synthetic bisbenzylisoquinoline derivatives; Blood 132 (Supplement 1); 2018; doi: 10.1182/blood-2018-99-111651

E. Plesch, C. C. Chen, E. Butz, A. Scotto Rosato, E. K. Krogsaeter, H. Yinan, K. Bartel, M. Keller, D. Robaa, D. Teupser, L. M. Holdt, A. Vollmar, W. Sippl, R. Puertollano, D. Medina, M. Biel, C. Wahl-Schott, F. Bracher, C. Grimm; Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells; Elife; (2018); doi: 10.7554/eLife.39720

M. Keller, A. Wolfgardt, C. Müller, R. Wilcken, F. M. Böckler, S. Oliaro-Bosso, T. Ferrante, G. Balliano, F. Bracher; Arylpiperidines as a new class of oxidosqualene cyclase inhibitors; European Journal of Medicinal Chemistry (2015);DOI: 10.1016/j.ejmech.2015.12.025

C. C. Chen, M. Keller, M. Hess, R. Schiffmann, N. Urban, A. Wolfgardt, M. Schaefer, F. Bracher, M. Biel, C. Wahl-Schott, C. Grimm; A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV; Nature Communications; (2014); DOI: 10.1038/ncomms5681

M. Krojer, M. Keller, F. Bracher; 7-Aza-des-A-steroids with antimicrobial and cytotoxic effects; Sciencia Pharmaceutica, 81, 329-338 (2013)

S. Lange, M. Keller, C. Müller, S. Oliaro-Bosso, G. Balliano, F. Bracher; Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors; Eur. J. Med. Chem. 63, 758-764 (2013)

P. Filippakopoulos, S. Picaud, O. Fedorov, M. Keller, M. Wrobel, O. Morgenstern, F. Bracher, S. Knapp; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Bioorg. & Med. Chem. 20, 1878-1886 (2012)

L. Schiefelbein, M. Keller, F. Weissmann, M. Luber, F. Bracher, W. Frieß; Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation; Eur. J. Pharm. Biopharm. 76, 342-350 (2010)

J. S. Mathieson, G. J. T. Cooper, A. L. Pickering, M. Keller, D. L. Long, G. N. Newton, L. Cronin; Monitoring the formation of coordination complexes using electrospray mass spectrometry; Chem. Asian J. 4, 681-687 (2009)

G. J. T. Cooper, G. N. Newton, D. L. Long, P. Koegerler, M. H. Rosnes, M. Keller, L. Cronin; Exploring a series of isostructural dodecanuclear mixed Ni:Co clusters: toward the control of elemental composition using pH and soichiometry; Inorg. Chem. 48, 1097-1104 (2009)

Congress lecture

M. Keller, C. Müller, F. Bracher; Synthesis of new and selective inhibitors of human oxidosqualene cyclase; Jahrestagung der DPhG, 28.09. - 01.10.2009, Jena, Germany

Poster and conference contributions

M. Keller, A. Wolfgardt, C. Müller, S. Oliaro-Bosso, G, Balliano, R. Wilcken, F. Böckler, F. Bracher; Aryltetrahydropyridine and arylpiperidine derivatives as a new class of human oxidosqualene cyclase inhibitors; Jahrestagung der DPhG, 09.10.-11.10.2013, Freiburg, Germany

M. Wrobel, M. Keller, P. Filippakopoulos, S. Knapp, F.Bracher; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Frontiers in Medicinal Chemistry, 18.03.-20.03.2013, München, Germany

M. Worbel, M. Keller, P. Filippakopoulos, O. Morgenstern, S. Knapp, F.Bracher; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Summer School, 26.09.-28.09.2013, Regensburg, Germany

A. Wolfgardt, Ch. Müller, M. Keller, F. Bracher; Synthesis of new selective oxidosqualene cyclase inhibitors; Joint Meeting of the Austrian and German Pharmaceutical Societies, 20.09. - 23.09.2011, Innsbruck, Austria

L. Schiefelbein, M. Keller, F. Bracher, W. Frieß; Relationship between hemolytic activity and critical micelle concentration (CMC) of sugar based surfactants for protein formulations; 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 07.04. - 10.04.2008, Barcelona, Spain

Crystal structures

	Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7)
	Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., Keller, M., Wrobel, M., Morgenstern, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bracher, F., Knapp, S.
	DOI: 10.2210/pdb3u5l/pdb	PDB code: 3U5L

Research

Synthesis of small molecules as tool compounds to study TRPML- and TPC ion channels

Radiolabelling of key-compounds for biological assays

Synthesis of BET bromodomain inhibitors (e.g. Benzodiazepine, Benzotriazepine)

Synthesis of inhibitors of the cholesterol biosynthesis pathway (e.g. oxidosqualene cyclase inhibitors)

Cooperations

Prof. Dr. Stefan Knapp, Department of Pharmacy, Goethe University Frankfurt (Kinase-Inhibitoren, Cokristallisationen)

Prof. Dr. Martin Biel, Ludwig-Maximilians-Universität München (small molecules as tools to study TRPML- and TPC- ion channels)

Dr. Dr. Christian Grimm, Ludwig-Maximilians-Universität München (small molecules as tools to study TRPML- and TPC- ion channels)

Education

Qualitative analytics for pharmacists (Qualitative Bestimmung von Arznei-, Hilfs- und Schadstoffen unter Einbeziehung von Arzneibuchmethoden (Pharmazie Staatsexamen))

General and inorganic chemistry (Pharmaceutical Sciences)