Group of Prof. Franz Bracher - Faculty for Chemistry and Pharmacy
Group of Prof. Franz Bracher - Faculty for Chemistry and Pharmacy
Chi, G.; Jaslan, D.; Kudrina, V.; Böck, J.; Li, H.; Pike, A.C.W.; Rautenberg, S.; Krogsaeter, E.; Bohstedt, T.; Wang, D.; McKinley, G.; Fernandez-Cid, A.; Mukhopadhyay, S.M.M.; Burgess-Brown, N.A.; Keller, M.; Bracher, F.; Grimm, C.; Dürr, K.L.; Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist, Structure 2024; 32, 1–13; https://doi.org/10.1016/j.str.2024.05.005
Yuan, Y.; Arige, V.; Saito, R.; Mu, Q.; Brailoiu, G. C.; Pereira, G. J. S.; Bolsover, S. R.; Keller, M.; Bracher, F.; Grimm, C.; Brailoiu, E.; Marchant, J. S.; Yule, D. I.; Patel, S.; Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum; Cell Reports 2024, 43 (1); https://doi.org/10.1016/j.celrep.2023.113628.
Saito, R.; Mu, Q.; Yuan, Y..; Rubio-Alarcon, M; Eznarriaga, M.; Zhao, P.; Gunaratne, G.; Kumar, S.; Keller, M.; Bracher, F.; Grimm, C.; Brailoiu, E.; Marchant, J. S.; Rahman, T.; Patel, S.; Convergent activation of Ca2+ permeability in two-pore channel 2 through distinct molecular routes, Science Signalling 2023, 799, 10.1126/scisignal.adg0661.
Yuan, Y.; Jaslan, D.; Rahman, T.; Bolsover, S.R.; Arige, V.; Wagner, L.W. II; Abrahamian, C.; Keller, M.; Hartmann, J.; Rosato, A.S.; Weiden, E.-M.; Bracher, F.; Yule, D.I.; Grimm, C.; Patel, S., Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes, Nat Commun 2022, 13, 4481, https://doi.org/10.1038/s41467-022-31959-0.
Rosato, A.S.; Krogsaeter, E.; Jaślan, D.; Montefusco, S.; ,Abrahamian, C.; Soldati, C.; Spix, B.; Böck, J.; Wyatt, A.; Wünkhaus, D.; Passon, M.; Stieglitz, M.; Keller, M.; Hermey, G.; Markmann, S.; Gruber-Schoffnegger, D.; Cotman, S.; Johannes, L.; Crusius, D.; Boehm, U.; Marquardt, T.; Wahl-Schott, C.; Biel, M; Bracher, F.; Polishchuk, E.; Medina, D.L.; Paquet, D.; Grimm, C., TPC2 rescues lysosomal storage in mucolipidosis type IV; Niemann-Pick type C1 and Batten disease, EMBO Mol. Med. 2022, e15377, https://doi.org/10.15252/emmm.202115377.
Keller, M.; Sauvageot-Witzku, K.; Geisslinger, F.; Urban, N.; Schaefer, M.; Bartel, K.; Bracher, F., The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet–Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids, Beilstein J Org Chem 2021, 17, 2716-2725, 10.3762/bjoc.17.183.
Leser, C.; Keller, M.; Gerndt, S.; Urban, N.; Chen, C. C.; Schaefer, M.; Grimm, C.; Bracher, F., Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3, Eur J Med Chem 2021, 210, 112966, 10.1016/j.ejmech.2020.112966.
Gerndt, S.; Chen, C. C.; Chao, Y. K.; Yuan, Y.; Burgstaller, S.; Scotto Rosato, A.; Krogsaeter, E.; Urban, N.; Jacob, K.; Nguyen, O. N. P.; Miller, M. T.; Keller, M.; Vollmar, A. M.; Gudermann, T.; Zierler, S.; Schredelseker, J.; Schaefer, M.; Biel, M.; Malli, R.; Wahl-Schott, C.; Bracher, F.; Patel, S.; Grimm, C., Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function, Elife 2020, 9, 10.7554/eLife.54712.
Müller, M.; Gerndt, S.; Arner, A.; Chao, Y.-K.; Schömig, L.; Atzberger, C.; Biel, M.; Bracher, F.; Vollmar, A.; Binder, V.; Keller, M.; Grimm, C.; Bartel, K., Reversal of Chemoresistance in Leukemia Cells using synthetic bisbenzylisoquinoline derivatives, Blood 2018, 132, 3504-3504, 10.1182/blood-2018-99-111651.
Plesch, E.; Chen, C. C.; Butz, E.; Scotto Rosato, A.; Krogsaeter, E. K.; Yinan, H.; Bartel, K.; Keller, M.; Robaa, D.; Teupser, D.; Holdt, L. M.; Vollmar, A. M.; Sippl, W.; Puertollano, R.; Medina, D.; Biel, M.; Wahl-Schott, C.; Bracher, F.; Grimm, C., Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells, Elife 2018, 7, 10.7554/eLife.39720.
Keller, M.; Wolfgardt, A.; Muller, C.; Wilcken, R.; Bockler, F. M.; Oliaro-Bosso, S.; Ferrante, T.; Balliano, G.; Bracher, F., Arylpiperidines as a new class of oxidosqualene cyclase inhibitors, Eur J Med Chem 2016, 109, 13-22, 10.1016/j.ejmech.2015.12.025.
Chen, C. C.; Keller, M.; Hess, M.; Schiffmann, R.; Urban, N.; Wolfgardt, A.; Schaefer, M.; Bracher, F.; Biel, M.; Wahl-Schott, C.; Grimm, C., A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV, Nat Commun 2014, 5, 4681, 10.1038/ncomms5681.
Krojer, M.; Keller, M.; Bracher, F., 7-Aza-des-A-steroids with antimicrobial and cytotoxic effects, Sci Pharm 2013, 81, 329-38, 10.3797/scipharm.1303-03.
Lange, S.; Keller, M.; Muller, C.; Oliaro-Bosso, S.; Balliano, G.; Bracher, F., Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors, Eur J Med Chem 2013, 63, 758-64, 10.1016/j.ejmech.2013.03.002.
Filippakopoulos, P.; Picaud, S.; Fedorov, O.; Keller, M.; Wrobel, M.; Morgenstern, O.; Bracher, F.; Knapp, S., Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family, Bioorg Med Chem 2012, 20, 1878-86, 10.1016/j.bmc.2011.10.080.
Schiefelbein, L.; Keller, M.; Weissmann, F.; Luber, M.; Bracher, F.; Friess, W., Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation, Eur J Pharm Biopharm 2010, 76, 342-50, 10.1016/j.ejpb.2010.08.012.
Cooper, G. J.; Newton, G. N.; Long, D. L.; Kogerler, P.; Rosnes, M. H.; Keller, M.; Cronin, L., Monitoring the formation of coordination complexes using electrospray mass spectrometry, Inorg Chem 2009, 48, 1097-104, 10.1021/ic802197u.
Mathieson, J. S.; Cooper, G. J.; Pickering, A. L.; Keller, M.; Long, D. L.; Newton, G. N.; Cronin, L., Exploring a series of isostructural dodecanuclear mixed Ni:Co clusters: toward the control of elemental composition using pH and stoichiometry, Chem Asian J 2009, 4, 681-7, 10.1002/asia.200900007.
Rautenberg, S.; Keller, M.; Leser, C.; Chen, CC.; Bracher, F.; Grimm, C., Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels, Handbook of Experimental Pharmacology (2022), Springer, Berlin, Heidelberg, https://doi.org/10.1007/164_2022_605.
Capel, R. A.; Akerman, E.; Mu-u-min, R. B. A.;Read, M.; Rog-Zielinska, E.; Koschinski, A.; Aston, D.; Jenkin, I.; Brans, V.; Bose, S. J.; Ruas, M.; Potter, B. V.; Keller, M.; Bracher, F.; Galione, A.; Zaccolo, M.; Terrar, D. A.; Burton, R. A. B.; Lysosomal calcium signalling contributes to acute physiological control of heart rate at the sino-atrial node pacemaker; Gordon Research Conference on Cardiac Arrhythmia Mechanisms, 03.2023; Texas, USA.
Keller, M.; Wolfgardt, A.; Müller, C.; Oliaro-Bosso, S.; Balliano, G.; Wilcken, R.; Böckler, F.; Bracher, F.; Aryltetrahydropyridine and arylpiperidine derivatives as a new class of human oxidosqualene cyclase inhibitors; Jahrestagung der DPhG, 09.10.-11.10.2013, Freiburg, Germany.
Wrobel, M.; Keller, M.; Filippakopoulos, P.; Knapp, S.; Bracher, F.; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Frontiers in Medicinal Chemistry, 18.03.-20.03.2013, München, Germany.
Schiefelbein, L.; Keller, M.; Weissmann, F.; Luber, M.; Bracher, F.; Frieß, W.; Synthesis, characterization and assessment of suitability of trehalose fatty acid esters as alternatives for polysorbates in protein formulation; DPhG International Graduate Student Symposium, 18.11. - 21.11.2009, Pichlarn, Austria.
Keller, M.; Müller, C.; Bracher, F.; Synthesis of new and selective inhibitors of human oxidosqualene cyclase; Jahrestagung der DPhG, 28.09. - 01.10.2009, Jena, Germany.
Worbel, M.; Keller, M.; Filippakopoulos, P.; Morgenstern, O.; Knapp, S.; Bracher, F.; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family; Summer School, 26.09.-28.09.2013, Regensburg, Germany.
Wolfgardt, A.; Müller, C.; Keller, M.; Bracher, F.; Synthesis of new selective oxidosqualene cyclase inhibitors; Joint Meeting of the Austrian and German Pharmaceutical Societies, 20.09. - 23.09.2011, Innsbruck, Austria.
Schiefelbein, L.; Keller, M.; Bracher, F.; Frieß, W.; Relationship between hemolytic activity and critical micelle concentration (CMC) of sugar-based surfactants for protein formulations; 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 07.04. - 10.04.2008, Barcelona, Spain.