Group of Prof. Franz Bracher - Faculty for Chemistry and Pharmacy
Group of Prof. Franz Bracher - Faculty for Chemistry and Pharmacy
Dutch Patent No. 2031175 (11.9.2023). Bracher F, Giera M, Müller C, Rensen PCN : "DHCR24 inhibitory compounds".
WO 2023/012221 (09.02.2023). von Mutius E, Rankl B, Bracher F, Müller C, Walker A, Hauck S, Merl-Pham J, Adler H, Yildirim AÖ, Sattler M, Santos Dias Mourão A, Borggräfe J, O'Connor PD, Plettenburg O: “Proteins identified from barn dust extract for the prevention and treatment of diseases”.
WO 2020/120724 (18.06.2020). von Mutius E, Bracher F, Müller C, Vercelli D: “Barn dust extract for the prevention and treatment of diseases”.
Peter M, Bakanov N, Mathgen X, Brühl CA, Veith M, Müller C. Multiresidue analysis of bat guano using GC-MS/MS. Analytical and Bioanalytical Chemistry, 2024, in press
Ge X, Slütter B, Lambooij JM, Zhou E, Ying Z, Agirman C, Heijink M, Rimbert A, Guigas B, Kuiper J, Müller C, Bracher F, Giera M, Kooijman S, Rensen PC, Wang Y., Schönke M. DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice. iScience, accepted for publication (2 March 2024)
Kühbacher A, Merschak P, Haas H, Liebl M, Müller C, Gsaller F. The cytochrome P450 reductase is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 2023; in press
Schrumpf JA, Ninaber DK, Müller C, Rankl B, von Mutius E, Smits HH, Hiemstra PS. Farm dust reduces mucin production in rhinovirus-infected primary bronchial epithelial cells. Pediatric Allergy and Immunology, 2023; 34:e14008.
Liebl M, Huber L, Elsaman H, Wagener J, Merschak P, Gsaller F, Müller C. Quantifying isoprenoids in the ergosterol biosynthesis by Gas Chromatography-Mass Spectrometry. Journal of Fungi, 2023; 9:768.
Dos Santos MM, Pivniouk V, Rankl B, Walker A, Pagani G, Hertkorn N, Schmitt-Kopplin P, Müller C, Bracher F, Merl-Pham J, Hauck SM, Schloter M, Michael AN, Anderson D, Honeker L, Gozdz J, Pivniouk O, Ober C, Holbreich M, Martinez FD, Snyder SA, von Mutius E, Vercelli D. Asthma-protective agents in dust from traditional farm environments. Journal of Allergy and Clinical Immunology, 2023; 152:610-621.
Zhou E, Ge X., Nakashima H, Li R, van der Zande HJ, Liu C, Li Z, Müller C, Bracher F, Mohammed Y, de Boer JF, Kuipers F, Guigas B, Glass CK, Rensen PC, Giera M, Wang Y. Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation. EMBO Molecular Medicine, 2023; e16845.
Sastré-Veláquez LE, Dallemulle A, Kühbacher A, Baldin C, Alcazar-Fuoli L, Niedrig A, Müller C, Gsaller F. The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment. PLoS Pathogens, 2022; 18:e1011066.
Jourjine IAP, Bauernschmidt C, Müller C, Bracher F. A GC-MS protocol for the identification of polycyclic aromatic alkaloids from Annnonaceae. Molecules, 2022; 27:8217.
Krehenwinkel H, Weber S, Brökmann R, Melcher A, Hans J, Wolf R, Hochkirch A, Kennedy SR, Koschorrek J, Künzel S, Müller C, Retzlaff R, Teubner D, Schanzer S, Klein R, Paulus M, Udelhoven T, Veith M. Environmental DNA from archived leaves reveals widespread temporal turnover and biotic homogenization in forest arthropod communities. eLife, 2022; 11:e78521.
Deiringer N, Aleshkevich S, Müller C, Friess W. Modification of tubings for peristaltic pumping of biopharmaceutics. Journal of Pharmaceutical Sciences, 2022; 111:3251-3260.
Schanzer S, Koch M, Kiefer A, Jentke T, Veith M, Bracher F, Bracher J, Müller C. Analysis of pesticide and persistent organic pollutant residues in German bats. Chemosphere, 2022; 305:135342.
Müller C, Hank EC, Giera M, Bracher F. Dehydrocholesterol reductase 24 (DHCR24): Medicinal chemistry, pharmacology and novel therapeutic options. Current Medicinal Chemistry, 2022; 29:4005-4025.
Krauß J, Müller C, Klimt M, Valero LJ, Martinez Hernandez JF, Müller M, Bartel K, Binder U, Bracher F. Synthesis, biological evaluation, and structure–activity relationships of 4-aminopiperidines as novel antifungal agents targeting ergosterol biosynthesis. Molecules, 2021; 26:7208.
Bouwknegt J, Wiersma SJ, Ortiz-Merino RA, Doornebal ESR, Buitenhuis P, Giera M, Müller C, Pronk JT. A squalene-hopene cyclase in Schizosaccharomyces japonicus represents a eukaryotic adaption to sterol independent anaerobic growth. Proceedings of the National Academy of Sciences of the United States of America, 2021; 118:e2105225118.
Schanzer S, Kröner E, Wibbelt G, Koch M, Kiefer A, Bracher F, Müller C. Miniaturized multiresidue method for the analysis of pesticides and persistent organic pollutants in non-target wildlife animal liver tissues using GC-MS/MS. Chemosphere, 2021; 279:130434.
Junker J, Kamp F, Winkler E, Steiner H, Bracher F, Müller C. Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS. Journal of Steroid Biochemistry and Molecular Biology, 2021; 211:105880.
Rockinger U, Müller C, Bracher F, Funk M, Winter G. DMSO as new, counterintuitive excipient for freeze-drying human keratinocytes. European Journal of Pharmaceutical Sciences, 2021; 160:105746.
Löbbert A, Schanzer S, Krehenwinkel H, Bracher F, Müller C. Determination of multi pesticide residues in leaf and needle samples using a modified QuEChERS approach and gas chromatography-tandem mass spectrometry. Analytical Methods, 2021; 13:1138-1146.
Müller M, Gerndt S, Chao Y-K, Zisis T, Nguyen ONP, Gerwien A, Urban N, Müller C, Gegenfurtner FA, Geisslinger F, Ortler C, Chen C-C, Zahler S, Biel M, Schaefer M, Grimm C, Bracher F, Vollmar AM, Bartel K. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chemical Biology, 2021; 28:1119-1131.e27.
Heerdegen D, Reuter D, Kornmayer MM, Kriegler KN, Müller C, Mayer P, Bracher F. Synthesis of Seco-Analogues of the DHCR24 Inhibitor SH-42. European Journal of Organic Chemistry, 2020; 6270-6288. Highlighted in Organic Chemistry. Highlights: https://www.organic-chemistry.org/Highlights/2021/26April.shtm
Schepmann D, Neue C, Westphälinger S, Müller C, Bracher F, Lange C, Bednarski P, Almansa C, Friedland K, Räbiger V, Düfer M, Wünsch B. Pharmacological characterization of high-affinity sigma-1 receptor ligands with spirocyclic thienopyran and thienofuran scaffold. Journal of Pharmacy and Pharmacology, 2020; 72(2):236-248.
Körner A, Zhou E, Müller C, Mohammed Y, Herceg S, Bracher F, Rensen PCN, Wang Y, Mirakaj V, Giera M. Inhibition of Δ24-dehydrocholesterol-reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution. Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(41):20623-20634.
Chiu JE, Thekkiniath J, Mehta S, Müller C, Bracher F, Ben Mamoun C. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. Journal of Biological Chemistry, 2019; 294:14757-14767.
Müller C, Junker J, Bracher F, Giera M. A gas chromatography – mass spectrometry based whole cell screening assay for target identification in distal cholesterol biosynthesis. Nature Protocols, 2019; 14:2546-2570.
Junker J, Chong I, Kamp F, Steiner H, Giera M, Müller C, Bracher F. Comparison of strategies for the determination of steroid sulfates via GC-MS leading to a novel deconjugation derivatization protocol. Molecules, 2019; 24:2353-2570.
Müller C, Wagner AL, Rockinger U, Winter G, Bracher F. Development of a convenient method for the determination of dimethyl sulfoxide in lyophilised pharmaceuticals by static headspace gas chromatography – mass spectrometry. Analytical Methods, 2019; 11:2119-2122.
Müller C, Neugebauer T, Zill P, Lass-Flörl C, Bracher F, Binder U. Sterol composition of clincally relevant mucorales and changes resulting from posaconazole treatment. Molecules, 2018; 23:1218-1230.
van der Vlugt L, Eger K, Müller C, Ninaber DK, Zarcone MC, Amatngalim GD, Bracher F, von Mutius E, Smits HH, Hiemstra PS. Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function. Journal of Allergy and Clinical Immunology, 2018; 141:1949-1952.
Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS ONE, 2017; 12:e0184438.
Misslinger M, Gsaller F, Müller C, Bracher F, Bromley M, Hass H. The cytochrome b5CybE is regulated by iron availability and is crucial for azole resistance of A. fumigatus. Metallomics, 2017; 9:1655-1665.
Müller C, Hemmers S, Bartl N, Plodek A, Körner A, Mirakaj V, Giera M, Bracher F. A new class of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. European Journal of Medicinal Chemistry, 2017; 140:305-320.
Fanter L, Müller C, Schepmann D, Bracher F, Wünsch B. Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel s1 receptor ligands. Bioorganic and Medicinal Chemistry, 2017; 25:4778-4799.
Vetter F, Müller C, Stöckelhuber M, Bracher F. Determination of coumarin in seasonal bakery products using QuEChERS and GC-MS. Die Pharmazie, 2017; 6:313-316.
Stöckelhuber M, Müller C, Vetter F, Mingo V, Lötters S, Wagner N, Bracher F. Determination of pesticides adsorbed on arthropods and gastropods by a micro-QuEChERS approach and GC-MS/MS. Chromatographia, 2017; 80:825-829.
Müller C, Binder U, Bracher F, Giera M. Antifungal drug testing: Combining minimal inhibitory concentration testing with target identification by the use of gas chromatography mass spectrometry. Nature Protocols, 2017; 12:947-963.
Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ. Sterol biosynthesis and azole tolerance is governed by the opposing actions of SrbA and the CCAAT binding complex. PLoS pathogens, 2016; 12:1-22.
Funke F, Matilainen J, Nalenz H, Bechtold-Peters K, Mahler H-C, Vetter F, Müller C, Bracher F, Friess W. Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature. European Journal of Pharmaceutics and Biopharmaceutics, 2016; 105:209-222.
Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb JA, Adams RH, Bracher F, Zahler S, Vollmar AM, Liebl J. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget 2016; 7:6088-6104.
Keller M, Wolfgardt A, Mülller C, Wilcken R, Böckler FM, Oliaro-Bosso S, Ferrante T, Balliano G, Bracher F. Arylpiperidines as a new class of oxidosqualene cyclase inhibitors. European Journal of Medicinal Chemistry, 2016; 109:13-22.
Keller P, Müller C, Engelhardt I, Hiller E, Lemuth K, Eickhoff H, Wiesmüller K-H, Burger-Kentischer A, Bracher F, Rupp S. An antifungal benzimidazole derivate inhibits ergosterol biosynthesis and reveals novel sterols. Antimicrobial Agents and Chemotherapy, 2015; 59:6296-6307.
Müller C, Binder U, Maurer E, Grimm C, Giera M, Bracher F. Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates. Steroids, 2015; 101:1-6.
Müller C, Bracher F. Determination by GC-IT/MS of phytosterols in herbal medicinal products (HMP) for the treatment of lower urinary tract symptoms (LUTS) and food products in marketed in Europe. Planta Medica, 2015; 81:613-620.
Krauss J, Hornacek M, Müller C, Staudacher V, Stadler M, Bracher F. Synthesis and antifungal evaluation of novel N-alkyl tetra- and perhydroquinoline derivatives. Scientia Pharmaceutica, 2015; 83:1-14.
Giera M, Müller C, Bracher F. Analysis and experimental inhibition of distal cholesterol biosynthesis. Chromatographia, 2014; 78:343-358.
Grimm C, Holdt LM, Chen C-C, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. High susceptibility to fatty liver disease in two-pore channel 2 deficient mice. Nature Communications, 2014; 5:4699-4712.
Kloos D-P, Gay E, Lingeman H, Bracher F, Müller C, Mayboroda OA, Deelder AM, Niessen WMA, Giera M. Comprehensive gas chromatography-electron ionisation mass spectrometric analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis. Rapid Communication in Mass Spectrometry, 2014; 28:1507-1514.
Müller C, Vetter F, Richter E, Bracher F. Determination of caffeine, myosmine, and nicotine in chocolate by headspace solid‑phase microextraction coupled with gas chromatography‑tandem mass spectrometry. Journal of Food Science 2014; 79:251-55.
Krauss J, Müller C, Kießling J, Richter S, Staudacher V, Bracher F. Synthesis and biological evaluation of novel N-alkyl tetra- and decahydroisoqinolines: Novel antifungals that target ergosterol biosynthesis. Archiv der Pharmazie 2013; 347:1‑8.
Krojer M, Müller C, Bracher F. Steroidomimetic aminoalkyl spiroacetals as novel inhibitors of the enzyme Δ8/7-sterol isomerase in cholesterol biosynthesis. Archiv der Pharmazie 2013; 346:1‑15.
Krauss J, Gratzl C, Sturm V, Müller C, Staudacher V, Schmidt CQ, Bracher F. Synthesis and biological evaluation of novel alkyl imidazolyl carbionols and their esters: potent antimycotics. Scientia Pharmaceutica 2013; 81:641‑50.
Lange S, Keller M, Müller C, Oliaro‑Bosso S, Balliano G, Bracher F. Aminoproylindenes derived from Grundmann’s ketone as a novel chemotype oxidosqualene cyclase inhibitors. European Journal of Medicinal Chemistry 2013; 63:758‑64.
Müller C, Staudacher V, Krauss J, Giera M, Bracher F. A convenient cellular assay for target identification and selective potency determination of quantification of ergosterol biosynthesis. Steroids 2013; 78:483‑493.
König M, Müller C, Bracher F. Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8/7-sterol isomerase. Bioorganic and Medicinal Chemistry 2013; 21:1925‑43.
Horling A, Müller C, Barthel R, Bracher F, Imming P. A new class of selective and potent 7-dehydrocholesterol reductase inhibitors. Journal of Medicinal Chemistry 2012; 55:7614‑22.
Müller C, Bracher F, Plössl F. Determination of nicotine in dried mushrooms by using a modified QuEChERS approach and GC-MS-MS. Chromatographia 2011; 73:807-11.