RCSB Protein Data Bank

The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), PDBe (Europe) and PDBj (Japan) 1. The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.

Crystal structures of the Bracher Group:

The crystal structures done in collaboration with Prof. Stefan Knapp, Structural Genomics Consortium (SGC), Oxford (www.sgc.ox.ac.uk), and with Prof. Oded Livnah, Jerusalem.

In collaboration with Prof. Stefan Knapp:
	PARP14 Macrodomain 2 with inhibitor
	Authors: Uth, K., Schuller, M., Sieg, C., Wang, J., Krojer, T., Knapp, S., Riedels, K., Bracher, F., Edwards, A.M., Arrowsmith, C., Bountra, C., Elkins, J.M. DOI: 10.2210/pdb5O2D/pdb PDB code: 5O2D
	Crystal structure of the bromodomain of human CREBBP in complex with a benzoxazepine compound
	Authors: Tallant, C., Popp, T.A., Fedorov, O., Siejka, P., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bracher, F., Knapp, S., Structural Genomics Consortium DOI: 10.2210/pdb5j0d/pdb PDB code: 5J0D
	Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor
	Authors: Chaikuad, A., Wurzlbauer, A., Nowak, R., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bracher, F., Knapp, S. DOI: 10.2210/pdb4yu2/pdb PDB code: 4YU2
	Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a beta-carboline inhibitor
	Authors: Williams, E., Chaikuad, A., Canning, P., Kochan, G., Mahajan, P., Cooper, C.D.O., Beltrami, A., Krojer, T., Pohl, B., Bracher, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Von Delfit, F., Bullock, A. DOI: 10.2210/pdb4asx/pdb PDB code: 4ASX
	Crystal structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7)
	Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bracher, F., Knapp, S. DOI: 10.2210/pdb3u5l/pdb PDB code: 3U5L
	Crystal structure of the Human Clk3 in Complex with V25 (KH-CB19T)
	Authors: Muniz, J.R.C., Fedorov, O., King, O., Filippakopoulos, P., Bullock, A., Phillips, C., Heightman, T., Ugochukwu, E., Von Delft, F., Arrowsmith, C.H., Bracher, F., Huber, K., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S. DOI: 10.2210/pdb2wu7/pdb PDB code: 2WU7
	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II (KH-CARB13)
	Authors: Filippakopoulos, P., Bullock, A., Fedorov, O., Huber, K., Bracher, F., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S. DOI: 10.2210/pdb3cy2/pdb PDB code: 3CY2
	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand (KH-CARB10)
	Authors: Filippakopoulos, P., Bullock, A., Fedorov, O., Huber, K., Bracher, F., Pike, A.C.W., Roos, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S. DOI: 10.2210/pdb3cxw/pdb PDB code: 3CXW
	Crystal structure of Human Death Associated Protein Kinase 3 (DAPK3) in Complex with a Beta-Carboline Ligand (KH-CARB10)
	Authors: Filippakopoulos, P., Rellos, P., Eswaran, J., Fedorov, O., Berridge, G., Niesen, F., Bracher, F., Huber, K., Pike, A.C.W., Roos, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S. DOI: 10.2210/pdb3bhy/pdb PDB code: 3BHY
	Crystal structure of Di-Phosphorylated Human Clk1 in Complex with a Novel Substituted Indole Inhibitor (KH-CB19T)
	Authors: Pike, A.C.W., Bullock, A., Fedorov, O., Pilka, E.S., Ugochukwu, E., Von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Huber, K., Bracher, F., Knapp, S. DOI: 10.2210/pdb2vag/pdb PDB code: 2VAG

In collaboration with Prof. Oded Livnah:
	Crystal structure of di-phosphorylated human CLK1 in complex with 5-(6,7-dichloro-1H-indol-3-yl)pyrimidin-4-amine
	Authors: Livnah, O., Domovich, Y., Bracher, F., Aigner, C. DOI: 10.2210/pdb7oa0/pdb PDB code: 7OA0
	Crystal structure of di-phosphorylated human CLK1 in complex with 4-(1H-indol-3-yl)pyrimidin-2-amine
	Authors: Livnah, O., Domovich, Y., Bracher, F., Aigner, C. DOI: 10.2210/pdb7o9y/pdb PDB code: 7O9Y
	Non-phosphorylated human CLK1 in complex with an indole inhibitor to 1.65 Ang
	Authors: Livnah, O., Domovich, Y. DOI: 10.2210/pdb6qty/pdb PDB code: 6QTY
	Crystal structure of di-phosphorylated human CLK1 in complex with 4-(6,7-dichloro-1H-indol-3-yl)pyrimidin-2-amine
	Authors: Livnah, O., Domovich, Y. DOI: 10.2210/pdb6r3d/pdb PDB code: 6R3D
	Crystal structure of di-phosphorylated human CLK1 in complex with 5-(1-methyl-1H-indol-3-yl)pyrimidin-4-amine
	Authors: Livnah, O., Domovich, Y. DOI: 10.2210/pdb6r6x/pdb PDB code: 6R6X
	Crystal structure of di-phosphorylated human CLK1 in complex with 4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
	Authors: Livnah, O., Domovich, Y. DOI: 10.2210/pdb6r8j/pdb PDB code: 6R8J